Death Stranding

Death Stranding is a 2019 Japanese science fiction video game featuring a small amount of prehistoric content.

Plot
After a supernatural disaster known as the Death Stranding, the nature of death irreversibly changes, leading to the total reorganization of society as people flee to underground shelters and isolate themselves from others to avoid disaster.

Prehistoric Content
Late in the game, the protagonist, Sam Porter Bridges, meets a researcher code-named Heartman, investigating the nature of the Death Stranding. He theorizes that similar events have occurred several times in the past, corresponding to the mass extinctions of the Earth's past, that the neanderthals also underwent such an event, and that the hand prints left in cave paintings were a recreation of the hand prints left by the ghostly BTs after the Death Stranding.